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ZEBRAFISH AS A PROMISING MODEL FOR ATHEROSCLEROSIS : A COMPREHENSIVE STUDY

 

Parijat Bhadra, & Dr. Shefali Raizada
Department of Life Sciences, School of Sciences, Garden City University, Bangalore, Karnataka, India

 

ABSTRACT

Atherosclerosis (AS) is a chronic inflammatory disorder which occurs mainly due to accumulation of lipids in the arterial wall, ultimately leading to vascular complications. Traditional mammalian models to study Atherosclerosis (AS) poses some significant challenges due to their cost, maintenance and long experimental durations. This review explores the potential of zebrafish as a model for studying atherosclerosis (AS) and its early symptoms, which is induced by high cholesterol and high lipopolysaccharide diet. The authors in the referred articles have meticulously investigated the ease of using zebrafish to screen potential anti AS (atherosclerosis) drugs.

KEYWORDS: Atherosclerosis, High Cholesterol diet (HCD), High lipopolysaccharide diet (HLD), Zebra fish, Lipid Metabolism, Atherogenesis

Citation:

 

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